M utations within the gene FTO have been implicated as the strongest genetic determinant of obesity risk in humans, but the mechanism behind this link remained unknown. Now, an international team of scientists has discovered that the obesity-associated elements within FTO interact with IRX3, a distant gene on the genome that seems to be the functional obesity gene. The FTO gene itself appears to have only a peripheral effect on overweight. The study appears online March 12 in Nature. "Our data strongly suggest that IRX3 controls body mass and regulates body composition," said senior study author Marcelo Nobrega, PhD, associate professor of human genetics at the University of Chicago. "Any association between FTO and obesity appears due to the influence of IRX3." Tests on mice showed IRX3 interacts with FTO even though its locality on the genome is a long way away. An analysis of a human genetic database then found the same thing happens in people which was confirmed...
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